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James H Doroshow Selected Research

Dual Oxidases

11/2019IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells.
10/2019Hydrogen peroxide-producing NADPH oxidases and the promotion of migratory phenotypes in cancer.
11/2017Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases.
1/2017Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
12/2016NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice.
10/2016Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A.
9/2015Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease.
6/2015NADPH oxidases and cancer.
4/2013Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
2/2013Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines.
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James H Doroshow Research Topics

Disease

181Neoplasms (Cancer)
10/2022 - 05/2002
12Inflammation (Inflammations)
10/2020 - 06/2004
12Breast Neoplasms (Breast Cancer)
03/2020 - 05/2002
11Lymphoma (Lymphomas)
11/2020 - 11/2009
9Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 08/2003
8Ovarian Neoplasms (Ovarian Cancer)
10/2017 - 10/2004
7Colonic Neoplasms (Colon Cancer)
11/2021 - 05/2012
7Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
10/2020 - 01/2012
7Neoplasm Metastasis (Metastasis)
01/2020 - 08/2003
7Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2018 - 01/2004
6Prostatic Neoplasms (Prostate Cancer)
03/2020 - 02/2004
6Carcinoma (Carcinomatosis)
01/2020 - 05/2002
6Pancreatic Neoplasms (Pancreatic Cancer)
11/2019 - 04/2011
6Hypoxia (Hypoxemia)
12/2017 - 10/2003
5Carcinogenesis
01/2021 - 04/2013
5Diarrhea
12/2020 - 09/2005
5Cardiotoxicity
03/2020 - 09/2004
5Adenocarcinoma
01/2020 - 11/2006
5Circulating Neoplastic Cells
01/2020 - 02/2010
4Hematologic Neoplasms (Hematological Malignancy)
10/2022 - 12/2003
4Sarcoma (Soft Tissue Sarcoma)
01/2022 - 09/2004
4Crohn Disease (Crohn's Disease)
12/2019 - 04/2003
4Genomic Instability
10/2017 - 04/2014
4Colitis
12/2016 - 04/2003
3Vomiting
12/2020 - 10/2003
3Nausea
12/2020 - 09/2005
3Necrosis
10/2020 - 08/2012
3Liver Diseases (Liver Disease)
11/2019 - 08/2003
3Triple Negative Breast Neoplasms
01/2018 - 03/2012
3Melanoma (Melanoma, Malignant)
12/2017 - 09/2005
3Infections
12/2016 - 10/2003
3Disease Progression
01/2016 - 09/2005

Drug/Important Bio-Agent (IBA)

44Pharmaceutical PreparationsIBA
10/2022 - 08/2003
23Biomarkers (Surrogate Marker)IBA
01/2021 - 12/2007
21Proteins (Proteins, Gene)FDA Link
12/2021 - 10/2003
21DNA (Deoxyribonucleic Acid)IBA
01/2021 - 01/2003
19Reactive Oxygen Species (Oxygen Radicals)IBA
03/2020 - 06/2004
15Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2020 - 06/2009
14NADPH Oxidases (NAD(P)H oxidase)IBA
11/2021 - 06/2009
13Dual OxidasesIBA
11/2019 - 06/2009
12Antineoplastic Agents (Antineoplastics)IBA
01/2022 - 01/2003
12Topotecan (Hycamtin)FDA LinkGeneric
10/2019 - 02/2010
11Messenger RNA (mRNA)IBA
12/2021 - 01/2003
10veliparibIBA
01/2021 - 11/2008
10CytokinesIBA
01/2020 - 04/2011
8Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2022 - 10/2003
8Oxygen (Dioxygen)IBA
11/2021 - 04/2011
8Doxorubicin (Adriamycin)FDA LinkGeneric
03/2020 - 01/2004
8EnzymesIBA
01/2020 - 07/2009
8Monoclonal AntibodiesIBA
01/2020 - 05/2002
8Cisplatin (Platino)FDA LinkGeneric
10/2019 - 01/2003
7Phosphotransferases (Kinase)IBA
12/2021 - 06/2005
7GemcitabineFDA Link
10/2019 - 11/2002
7PlatinumIBA
01/2018 - 11/2002
7Type I DNA Topoisomerases (Topoisomerase I)IBA
03/2016 - 07/2009
7Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2016 - 11/2008
6NADPH Oxidase 1IBA
11/2021 - 04/2013
6Paclitaxel (Taxol)FDA LinkGeneric
01/2020 - 10/2003
6Protein Isoforms (Isoforms)IBA
01/2020 - 03/2012
6Docetaxel (Taxotere)FDA Link
07/2006 - 05/2002
5Hormones (Hormone)IBA
02/2021 - 05/2002
5Carboplatin (JM8)FDA LinkGeneric
01/2021 - 10/2003
5ParaffinIBA
01/2020 - 05/2002
5Biological ProductsIBA
01/2020 - 10/2003
5Oxidoreductases (Dehydrogenase)IBA
01/2019 - 05/2012
5Poly Adenosine Diphosphate RiboseIBA
03/2012 - 06/2009
5Oxaliplatin (Eloxatin)FDA LinkGeneric
11/2009 - 08/2003
4diphenyleneiodoniumIBA
11/2021 - 05/2012
4Glutathione (Reduced Glutathione)IBA
10/2020 - 06/2004
4Oxidants (Oxidizing Agents)IBA
10/2020 - 04/2013
4PeroxidasesIBA
10/2020 - 06/2004
4Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
11/2019 - 10/2016
4Glutathione PeroxidaseIBA
08/2019 - 04/2003
4Topoisomerase I InhibitorsIBA
12/2018 - 09/2011
4AntibodiesIBA
01/2018 - 12/2003
4Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2016 - 01/2004
3Drug CombinationsIBA
12/2021 - 08/2011
3Histones (Histone)IBA
12/2021 - 10/2015
3pazopanibFDA Link
12/2021 - 07/2012
3iodonium thiopheneIBA
11/2021 - 05/2012
3Temozolomide (Temodar)FDA LinkGeneric
10/2021 - 11/2020
3TamoxifenFDA LinkGeneric
02/2021 - 10/2010
3adavosertibIBA
01/2021 - 10/2015
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2021 - 06/2015
3AnthracyclinesIBA
01/2020 - 08/2012
3Formaldehyde (Formol)FDA Link
01/2020 - 03/2018
3Anti-Bacterial Agents (Antibiotics)IBA
01/2020 - 08/2012
3Interleukin-4 (Interleukin 4)IBA
11/2019 - 05/2012
3CamptothecinIBA
12/2018 - 09/2014
3NSC 724998IBA
12/2018 - 12/2014
3Small Interfering RNA (siRNA)IBA
12/2017 - 09/2012
34,6-dinitro-o-cresol (DNOC)IBA
12/2017 - 05/2012
3Interleukin-13IBA
06/2017 - 05/2012
3Bortezomib (Velcade)FDA Link
01/2017 - 02/2006
3Irinotecan (Camptosar)FDA LinkGeneric
03/2016 - 09/2014
3Bevacizumab (Avastin)FDA Link
04/2014 - 05/2011

Therapy/Procedure

50Therapeutics
10/2022 - 10/2003
20Drug Therapy (Chemotherapy)
10/2022 - 05/2002
4Immunotherapy
01/2021 - 01/2016
3Aftercare (After-Treatment)
12/2018 - 08/2011